Integrantes

Breve descripción del grupo

Our research group is devoted to the study of human intestinal mucosal immunology, both in resting conditions as well as under inflammatory processes like coeliac disease and inflammatory bowel disease. To that end, we have established a close interaction with several gastrointestinal units which provide us with biological material (blood and intestinal tissues) from patients and controls. We pay particular attention to both the intraepithelial lymphocytes, as well as to the study of the ontogeny, phenotype and function of human mucosal dendritic cell and macrophage subsets and their circulating precursors in health and under inflammatory conditions. To that end, we have several models of mucosal immunology with human primary samples and access to a top-of-the-art spectral cytometer.

Recently, we have also expanded our interest to study of COVID-19 immune response. In particular, we are interested in the development of novel biomarkers to predict disease outcome, assess the evolution of the immune response, characterize the similarities and differences of the cellular and humoral immune memory in naturally (infected) and artificially (vaccinated) individuals and to unravel the basis underlaying the long-COVID syndrome.

Last, but not least, David Bernardo is also a member of the Executive Committee of the CSIC's Global Health Thematic Interdisciplinary Platform (PTI Global Health, https://pti-saludglobal-covid19.corp.csic.es) which agglutinates over than 200 research groups to fight Global Health problems as this one. Indeed, the PI is also the coordinator (together with Dr. María Montoya) of the WP5: IMMUNE where they supervise the work of 25 independent research groups with a budget over 5 million euros. 

Proyectos destacados

Título del proyecto: Descifrando la capacidad inmunoreguladora de vista en el intestino humano en la enfermedad inflamatoria intestinal (PID2023-148270OB-I00).

Duración: 2024 – 2027.

Entidad financiadora: Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación y FEDER, UE.

Presupuesto: 125.000 €.

Investigador Principal: David Bernardo Ordiz.

Proyecto PID2023-148270OB-I00 financiado por:

2022-2026 Proyecto de Infraestructura en Red de Castilla y Leon (INFRARED) (IR2021-UVA04) (484.237 €).

"Citómetro tipo sorter espectral de 3 láseres y 38 detectores". 

IP: David Bernardo.

2020-2024 Proyecto de Infraestructura en Red de Castilla y Leon (INFRARED) (IR2020-1-UVA01) (490.520 €).

"Citómetro espectral equipado con 5 láseres (355 nm, 405 nm, 488 nm, 561 nm, 638 nm) y con 67 detectores".

IP: David Bernardo.

2020-2023 Proyecto de investigación financiado por el Ministerio de Ciencia e Innovación (PID2019-104218RB-I00) (139.150 €).

"Migración y diferenciación de las subpoblaciones de células dendríticas y monocitos en la mucosa intestinal de pacientes con enfermedad inflamatoria intestinal". 

IP: David Bernardo.